Green Chemistry (2020): “Cell-free biocatalytic synthesis of pipecolic acid: a dual strategy approach and process intensification in flow”
This work was supported by the Wellcome Prime Award Fran received in 2018 through the University of Nottingham. This grant funded Ana for several month as a Post Doc in Nottingham and together with David they worked on a very nice system to produce pipe colic acid (high value molecule) from simple lysine. Liam was a fourth […]
J Flow Chem (2020): “Aromas flow: eco-friendly, continuous, and scalable preparation of flavour esters”
In this manuscript, the core idea of Martina’s Marie Curie project has been captured in its essence with the design of a highly sustainable strategy for the preparation of natural flavour esters, using exclusively reagents found in nature. The precious collaboration with Prof. Molinari and Prof. Tamborini (co-corresponding author) has been key for the optimisation […]
ChemBioChem (2019): “Transaminase-catalyzed continous synthesis of biogenic aldehydes”
Well done to Martina for securing another paper in the field of flow biocatalysis. Here we have looked at the possibility of preparing biogenic aldehydes from biological amines. Exploiting previous work we have co-immobilised the PLP cofactor generating a fully self sufficient reactor. Read the full paper here
Green Chemistry (2019): “Flow-based enzymatic synthesis of melatonin and other high value tryptamine derivatives: a five-minute intensified process”
To increase the uptake of biocatalytic processes by industry, it is essential to demonstrate the reliability of enzyme-based methodologies directly applied to the production of high value products. Here, an ultra-efficient, and sustainable enzymatic platform for the multi-gram synthesis of melatonin (and analogues) was developed. The fully-automated process integrates biocatalysis and flow chemistry, maximizes the […]
Catalysts (2019): “Overcoming Water Insolubility in Flow: Enantioselective Hydrolysis of Naproxen Ester”
Very well done David for bringing this paper to a close, the insolubility issue of the substrates was really problematic for flow biocatalysis and the use of small amounts of surfactants solved it much better than high percentage of organic solvents. You can read the paper here
ACS Sustainable Chemistry & Engineering (2018): Self-sufficient flow-biocatalysis by co-immobilisation of pyridoxal 5´-phosphate and ω-transaminases onto porous carriers
Amazing work with our collaborator Fernando Lopez-Gallego in Zaragoza, delighted about this paper which we hope to be the first of many joint publications. Well done to Anabel, Martina and Susana! You can find the paper here
Nature Catalysis (2018): Self-sustaining closed-loop multienzyme-mediated conversion of amines into alcohols in continuous reactions
Massive congratulation to Martina for this achievement! The paper summarises an outstanding amount of work with very clever applications. Find the paper here Or you can access a read only version here Related Posts
ChemCatChem Cover and Cover Profiles are out!
We are very happy with the front cover of our article which comes out in the October issue, have a look also at the “Cover Profile” which tells you a bit about how the collaboration with Prof. Molinari started and we loved about this project (click on the red text!) 2017 ChemCatChem profiles Related Posts
Trends in Biotechnology (2018): “Flow Bioreactors as Complementary Tools for Biocatalytic Process Intensification”
We have a nice review which just went online, a mammoth effort between Milan, Lisbon, and Nottingham https://doi.org/10.1016/j.tibtech.2017.09.005
ChemCatChem (2017): Highly Efficient Oxidation of Amines to Aldehydes with Flow-based Biocatalysis
Another great achievement for the group. This paper was chosen for the front cover of the journal, stay tuned to see how it looks like! The article is already available online https://doi.org/10.1002/cctc.201701147