Biocatalysis -
from Discovery to Application

We have a passion for sustainable processes and enzymes, bringing us a step closer to green synthetic strategies.

Research Highlights

Chemical Communication (2022): “Novel triple mutant of an extremophilic glycosyl hydrolase enables the rapid synthesis of thioglycosides”

October 20, 2022

Green Chemistry (2022): “Combined chemoenzymatic strategy for sustainable continuous synthesis of the natural product hordenine”

October 20, 2022

Group News

MetRaZyme Doctoral Network is live!

November 23, 2022

Biocat2022

September 2, 2022

Twitter

ParadisiResearch Follow

Discovery Evolution Application #biocatalysis #enzymes #flow #enzymeimmobilization @DCBunibern

Avatar ParadisiResearch @paradisireslab ·

13h

Together with @luciani_lab we were honoured to be part of a delegation who welcomed the Italian President #Mattarella to Bern! Grazie Presidente

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Avatar ParadisiResearch @paradisireslab ·

26 Nov

One PhD position in our group within the @MetRaZymes Doctoral Network. Application deadline 23.12.2022, starting date ~April 2023 https://paradisiresearch.com/group-news/metrazyme-doctoral-network-is-live/

Retweets appreciated!

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Avatar DCBPunibern @dcbpunibern ·

23 Nov

Do not miss today's "DCBP House Seminar":
Wednesday, November 23, 2022 at 16:30 in Lecture Hall EG16 @DCBPunibern @unibern
Speakers: Prof. Francesca Paradisi & PD Dr. Shi-Xia Liu
Apéro after the talks!
See http://www.dcbp.unibe.ch/agenda/dcbp for details

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Avatar Nico Bruns @bruns_lab ·

14 Nov

#PhDposition! Two PhD positions on enzymatic radical polymerizations as part of the @MSCActions Doctoral Network @MetRaZymes available in my group. Spread the word and apply now!
https://www.tu-darmstadt.de/universitaet/karriere_an_der_tu/stellenangebote/aktuelle_stellenangebote/stellenausschreibungen_detailansichten_1_493440.en.jsp
https://www.tu-darmstadt.de/universitaet/karriere_an_der_tu/stellenangebote/aktuelle_stellenangebote/stellenausschreibungen_detailansichten_1_493504.en.jsp

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Avatar ParadisiResearch @paradisireslab ·

13 Nov

We will soon advertise a position for a PhD in our group with a EU framework so mobility is essential and also not having been in Switzerland for more than 12 months in the last 3 years. I hope to have the ad ready next week!

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Projects

Enzyme Toolbox

We have introduced many enzymes in our toolbox over the years (and we always look for more!) to make our chemistry more and more versatile.

Flow Biocatalysis

We combine different enzymes, those that offer optimal characteristics for our chemistry, in continuous artificial biocatalytic pathways.

Enzyme immobilization

Enzyme stability can be greatly enhanced if the biocatalyst is anchored to a support. We develop novel strategies for enzyme immobilization.

Chemo-enzymatic Processes

Flow equipment and compartmentalisation of reaction steps offer an exceptional opportunity to integrate enzymes in organic syntheses.

Publications

Papers

Collection of the group research and review articles to date

Books & Chapters

Making a difference in the education of the next generation of scientists

Patents

Our discoveries with IP status in the field of biocatalysis and chemistry

Funding

Roche

Francesca Paradisi

Professor of Sustainable Pharmaceutical Chemistry

Department of Chemistry, Biochemistry and Pharmaceutical Sciences
University of Bern

Freiestrasse 3, 3012 Bern, Switzerland

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