J. Chem Ed (2026): “Introducing Enzyme Immobilization and Flow Biocatalysis to the Undergraduate Curriculum”
An undergraduate flow biocatalysis laboratory practical experiment was developed to introduce to the students the basics of enzyme characterization, enzyme immobilization, and continuous flow processes, from a practical approach. The practical was structured in two parts─enzyme immobilization and flow biocatalysis─and intended to be executed over 4 afternoons. Within this practical, the students were able to […]
Nature Reviews Methods Primers (2025): “Flow biocatalysis”
Flow biocatalysis uses enzymes to catalyse chemical reactions under continuous flow with applications in the synthesis of fine chemicals, pharmaceuticals, agrochemicals and natural products, among others. The flow set-up, which, in its core elements, is no different from a classical flow chemistry apparatus, has enabled reaction conditions and reactivities impossible to achieve in batch mode. In […]
Green Chemistry (2017) : “Continuous flow biocatalysis: production and in-line purification of amines by immobilised transaminase from Halomonas elongata”
Great achievement for the group! Matteo, Martina and Jenni, together with our collaborators in Milan (Prof. Molinari and Dr. Tamborini) are celebrating a very nice paper on flow chemistry using our transaminase from Halomonas. Well done! The paper ��Continuous flow biocatalysis: production and in-line purification of amines by immobilised transaminase from Halomonas elongata” is published […]
ChemCatChem (2017): Highly Efficient Oxidation of Amines to Aldehydes with Flow-based Biocatalysis
Another great achievement for the group. This paper was chosen for the front cover of the journal, stay tuned to see how it looks like! The article is already available online https://doi.org/10.1002/cctc.201701147
Trends in Biotechnology (2018): “Flow Bioreactors as Complementary Tools for Biocatalytic Process Intensification”
We have a nice review which just went online, a mammoth effort between Milan, Lisbon, and Nottingham https://doi.org/10.1016/j.tibtech.2017.09.005
ACS Sustainable Chemistry & Engineering (2018): Self-sufficient flow-biocatalysis by co-immobilisation of pyridoxal 5´-phosphate and ω-transaminases onto porous carriers
Amazing work with our collaborator Fernando Lopez-Gallego in Zaragoza, delighted about this paper which we hope to be the first of many joint publications. Well done to Anabel, Martina and Susana! You can find the paper here
ChemBioChem (2019): “Transaminase-catalyzed continous synthesis of biogenic aldehydes”
Well done to Martina for securing another paper in the field of flow biocatalysis. Here we have looked at the possibility of preparing biogenic aldehydes from biological amines. Exploiting previous work we have co-immobilised the PLP cofactor generating a fully self sufficient reactor. Read the full paper here
Green Chemistry (2022): “Combined chemoenzymatic strategy for sustainable continuous synthesis of the natural product hordenine”
First paper for Stefania! To improve sustainability, safety and cost-efficiency of synthetic methodologies, biocatalysis can be a helpful ally. In this work, a novel chemoenzymatic stategy ensures the rapid synthesis of hordenine, a valuable phenolic phytochemical under mild working conditions. In a two-step cascade, the immobilized tyrosine decarboxylase from Lactobacillus brevis (LbTDC) is here coupled with the […]
ChemSusChem (2022): “Biocatalytic production of a Nylon 6 precursor from caprolactone in continuous flow”
Green Chemistry (2021): “Biocatalytic access to betazole by one-pot multienzymatic system in continuous flow”
Maria successfully tackled a multi enzyme system which requires a NOX enzyme to recycle the NADH cofactor. Not a small battle when you require to maximise the air/oxygen content in a sealed system like a flow reactor. Very proud of this work! Abstract: “As an alternative to classical synthetic approaches for the production of betazole drug, a […]