Spent enzyme immobilisation resins constitute microplastic waste. Here, commercially available C2‑amine methacrylate beads are converted into reusable supports through furan decoration and a thermally cleavable Diels–Alder linker bearing an NHS ester. The enzyme–linker assembly is removed by retro‑Diels–Alder reaction, regenerating the support over multiple cycles.

Well done to Manos for bringing this home!

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