Catalysis Today (2026): “Keeping Catalysts Apart: Phase Separation Enables Metal–Enzyme Cofactor Regeneration cascade”

The integration of organometallic and enzymatic catalysis in one pot is often limited by mutual inhibition between metal complexes and enzymes, particularly in NAD(P)⁺-dependent redox cascades that require efficient cofactor regeneration. Here we report a family of IrCp* pyridinium-amidate (PYA) complexes that regenerate NAD(P)H in aqueous media. Systematic tuning of the pyridinium and phenolate substituents […]