Chem Comm (2021): “Minimalistic peptidic scaffolds harbouring an artificial carbene-containing amino acid modulate reductase activity”
Another collaborative paper with the group of Martin Albrecht here at the DCBP, we really like to combine carbenes and natural molecules such as peptides and check out how the catalysis is affected. Matteo worked on the synthesis and David did his usual magic with molecular dynamics and simulations! A great paper to read! Chemical Communication 2021, 57, 9068 – 9071 […]
Chemistry: a European Journal (2020): “Carbene-induced rescue of catalytic activity in deactivated Nitrite Reductase mutant”
Finally we have succeeded in getting this final work of Matteo over the line! This is the second one in the series of the carbene role in binding copper in protein clefts. Here we have shown how a catalytically active enzyme NiR can be partially rescued by replacing a coordinating histidine with the carbene exogenous ligand. In fact, this ligands […]