Achieving stereocontrol in chemical transformations remains one of the cornerstones of synthesis. Traditional methods to achieve stereoselectivity are based on organo- or metal catalysts, which may raise environmental concerns. As the global demand to create more renewable processes escalates, there is an increased need to develop procedures that minimize waste buildup and the use of toxic byproducts. Over the past few decades, the use of enzymes for achieving stereocontrol has gained traction. Enzymatic reactions are typically performed under aqueous conditions using benign and often recyclable substrates. These conditions, however, often limit their applicability and have relegated biocatalysis to a niche field for quite a long time. More recently, the integration of biocatalysis with other catalytic approaches has allowed multistep transformations, which would not have been possible with the use of either technique alone. In this perspective, we highlight recent advances in the field that have successfully blended biocatalysis with electro-, photo-, metallo-, and organocatalysis.

Excellent perspective co-authored with Davey!

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