Chemistry- A European Journal (2021): “GPhos ligand enables the production of chiral N-arylamines in a telescoped transaminase–Buchwald-Hartwig amination cascade in the presence of excess amine donor”

A fine paper from Chris. Here he explored how we can combine transaminases and chemocatalysis, specifically looking for water-compatible Pd catalysts to synthesise arylamines. All the credits goes to him and he shares here the corresponding authorship! Chemistry- A European Journal 2021 in press (doi:10.1002/chem.202103472) Read the full paper here Related Posts

Chem Comm (2021): “Minimalistic peptidic scaffolds harbouring an artificial carbene-containing amino acid modulate reductase activity”

Another collaborative paper with the group of Martin Albrecht here at the DCBP, we really like to combine carbenes and natural molecules such as peptides and check out how the catalysis is affected. Matteo worked on the synthesis and David did his usual magic with molecular dynamics and simulations! A great paper to read! Chemical Communication 2021, 57, 9068 – 9071 […]

Chris’s viva was super!

Chris defended his PhD thesis today and it was a stellar performance according to the examiners (Profs. Nick Turner, Neil Oldham and Neil Thomas). And so the last one of my students in Nottingham has finished. Chris will join the group of Dr. Caroline Paul in Delft and I have no doubt that he will […]

ChemBioChem (2022): “Stereo-divergent enzyme cascades to convert racemic 4-phenyl-2-butanol into either (S)- or (R)- corresponding chiral amine”

ChemBioChem (2022): “Stereo-divergent enzyme cascades to convert racemic 4-phenyl-2-butanol into either (S)- or (R)- corresponding chiral amine” The synthesis of enantiopure chiral amines from racemic alcohols is a key transformation in the chemical industry, e. g., in the production of active pharmaceutical ingredients (APIs). However, this reaction remains challenging. In this work, we propose a one-pot […]

Scientific Reports (2022): “High-throughput screening methods for enzyme-mediated alcohol oxidation”

Scientific Reports (2022): “High-throughput screening methods for enzyme-mediated alcohol oxidation” Alcohol oxidation for the generation of carbonyl groups, is an essential reaction for the preparation of fine chemicals. Although a number of chemical procedures have been reported, biocatalysis is a promising alternative for more sustainable and selective processes. To speed up the discovery of novel […]

Goodbye Javi!

goodbye Javi! Javi’s visit to the group has flown by super quick. It was great to have him visiting for three months from Spain and we wish him all the best for the completion of his PhD. Come back soon!