Aare boot trip!

Another lovely Aare boot trip with the group, everyone had fun! Related Posts

Organic & Biomolecular Chemistry (2023): “Glycosyl Benzoates as Novel Substrates for Glycosynthases” 

Well done to Sabrina (our master student), Lauriane and Davey! Abstract: The development of a procedure for the one-pot synthesis of glycosyl benzoates directly from unprotected sugars in aqueous media using 2-chloro-1,3-dimethylimidazolium chloride (DMC), thiobenzoic acid, and triethylamine is reported. These glycosyl donors are excellent substrates for wild-type and mutant glycosidases.  ß-Glucosyl benzoate was hydrolysed […]

European Journal of Organic Chemistry (2023): “Investigations into the Aqueous Synthesis of Selenoglycoconjugates”

Great achievement for Davey who is also co-corresponding author in this paper! Abstract: Glycosylation of bioactive molecules has been found to improve the pharmacokinetic properties of the parent molecule. However, their syntheses often require tedious protecting group manipulations. The development of methodologies which allow direct aqueous conversion of unprotected sugars into glycosides is therefore an […]

Oxford 2023 – Career talk

When a former undergraduate student emails to see if you would be happy to give a career talk in Oxford, I didn’t even had to think! Laura Cunningham is now a Post Doc in the group of Prof. Fletcher as well as being the President of Oxford Women in Chemistry. I was absolutely honoured that […]

Bürgenstock 2023

Another wonderful Bürgenstock conference this year. As Fran is part of the organising committee Pablo got to go as one of just three assistants and has the most challenging task of writing the names of the people asking questions to the speakers on the board! And he did a brilliant job! Looking forward the next […]

Frontiers in Catalysis (2023): “Sustainable synthesis of L-phenylalanine derivatives in continuous flow by immobilized phenyl ammonia lyase”

Great work from David in collaboration with Novartis! Abstract: The application of phenylalanine ammonia lyases (PALs) for the amination of a variety of cinnamic acids has been shown to be a cost-efficient method to produce a variety of phenylalanine analogues. Nonetheless, as many other biocatalytic tools, the process intensification, especially due to the high equivalents […]

Applied Microbiology and Biotechnology (2023): “Halomonas elongata: a microbial source of highly stable enzymes for applied biotechnology”

A super review from Ana on the wonders of enzymes from H. elongata. Abstract: Extremophilic microorganisms, which are resistant to extreme levels of temperature, salinity, pH, etc., have become popular tools for biotechnological applications. Due to their availability and cost-efficacy, enzymes from extremophiles are getting the attention of researchers and industries in the field of […]

ChemBioChem (2023): “Bioinformatic analysis of immobilized enzymes: towards a better understanding of the guiding forces”

David applied CapiPy to a set of enzymes to validate its applicability.  Abstract: Protein bioinformatics has been applied to a myriad of opportunities in biocatalysis, from enzyme engineering to enzyme discovery, but its application in enzyme immobilization is still very limited. Enzyme immobilization brings clear advantages form the sustainability and cost-efficiency terms but is nowadays […]

Frontiers Bioeng. Biotechnol. (2019): “Enhancing PLP-binding capacity of class-III ω-transaminases by single residue substitution”

The importance of PLP stability in transaminases prompted us to investigate less obvious residues which may be involved in anchoring the PLP. This work was a great collaboration with Dr. Lopez-Gallego (who just recently moved back to San Sebastian) and Dr.Dreveny in Nottingham. Very well done to David who carried out this work and got the good news of it being accepted on the […]